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The present study has several limitations

These findings reveal shared toxicity pathways across species and underscore the protective potential of natural polyphenols (132, 133)

Global obesity prevalence has more than doubled since 1990, highlighting the growing demand for weight management supplements and the opportunity to align with trends in metabolic and gut health

These treatment patterns need to change. Meanwhile, more data on tirzepatides impact on a broad five-component cardiovascular end point including all-cause mortality are expected from the placebo-controlled SURMOUNT-MMO outcome trial in 15,000 patients with obesity but no diabetes