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These include genetic, oxidative stress, autoimmune, autoinflammatory, neural, apoptotic, molecular adhesion disorder and multifactorial mechanisms [1]

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To a lesser extent, it is present in the kidneys, biliary tract epithelium, intestine, pancreas, brain, heart, and spleen

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Efficacy, tolerability, and safety of TRPC4/5 inhibitor BI 1358894 in patients with major depressive disorder and inadequate response to antidepressants: A Phase II randomized, placebo-controlled, parallel group, dose-ranging trial