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Although there is no natural form of semaglutide, certain dietary approaches, lifestyle modifications, and naturally occurring compounds may support the body's endogenous GLP-1 production or activity

In STEP-1 (semaglutide), lean mass decreased by ~9.7% while fat mass fell by ~19.3%, with the proportion of lean mass increasing by ~3 percentage points ( Limited preclinical and clinical data, particularly from MRI-based studies, suggest that skeletal muscle changes induced by GLP-1RAs may be adaptive

Metformin is not FDA-approved for weight loss.

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