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Preclinical studies have shown that large doses of GLP-1RAs can reduce lipid deposition and plaque volume on the aortic surface of hyperglycemic mice via an AMPK-independent action in streptozotocin (STZ)-induced hyperglycemic and hyperlipidemic mice or type 1 diabetic rats [55]
By identifying a specific enzyme (PDE4) that breaks down this signal, researchers proved they can block the enzyme to keep the weight-loss messaging active inside the cell, offering a brand-new strategy to shatter weight-loss plateaus
N Engl J Med 384 , 9891002 (2021)
The findings, presented at ENDO 2026, the Endocrine Societys annual meeting, showed an increase in hypotensive episodes after patients started GLP-1s
MT1 and MT2 are two distinct families of membrane receptors located in the plasma membrane, both of which are abundantly expressed in the CNS
