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High proline content (three consecutive prolines at positions 3-5) introduces conformational constraints
Adverse reactions following intramuscular (IM) injection have included anxiety, mild transient diarrhea, ataxia, nervousness, pruritus, transitory exanthema, and a feeling of swelling of the entire body
LogP The logarithm of the ratio of the concentrations of un-ionized solute (drug) in two immiscible liquid phases (usually octanol and water) at equilibrium
D'Angelo and Selhub, 1997)
10.1161/CIRCRESAHA.120.317046 48
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