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By inhibiting JAK1, JAK2, JAK3, and TYK2, delgocitinib modulates a wide array of cytokine pathways integral to CHEs diverse immunopathogenesis, including Th1, Th2, Th17, and Th22 -mediated inflammation [102, 103]

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Compared with healthy individuals, aberrant levels of abundant ncRNAs are observed, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs)

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