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That is all it took to turn a fragile, two-minute hormone into a peptide that lasts nearly a week

For instance, an elevated ROS production by the respiratory chain is observed in obesity as a response to metabolic overload caused by excess macronutrients and increased substrate availability ( Several enzymatic and non-enzymatic defence mechanisms that guard cells against free radical damage have been identified in different cellular localizations, including mitochondria, plasma membrane, endoplasmic reticulum, peroxisomes, and cytosol

Am J Physiol Endocrinol Metab 313(3):E263-e272

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