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By clearing senescent cells out, FOXO4-DRI reduces neuroinflammation and mitigates the stress on surrounding neurons

These agonists also play a vital role in nerve cell differentiation and inhibition of neuroinflammation

Hsp70 is also involved in the regulation of gene expression, and in the regulation of protein degradation ( 2

Long-term safety is uncertain

and actually SARS-CoV-2 causing COVID-19, all are characterized by persistent inflammation, continuous production of reactive oxygen/nitrogen species and oxidative stress that predominate over the antioxidant defenses (GSH and free radical scavenger enzymes) resulting in cell/tissue/organ aging associated with early (premature) chronic inflammation/inflammaging. We propose that, although inflammaging was introduced for the aging process (276289), it could also apply to early (premature) tissue and organ aging associated with cell and tissue damage caused by excessive oxidative stress and lack of adequate antioxidant defenses, especially low GSH levels, in younger individuals