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In addition, the only known transporter that places GSH in the ELF is CFTR, the gene defective in cystic fibrosis [42]

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In stark contrast, significant chromosome damage was evident upon treatment with the DNA crosslinking agent MMC, thus suggesting that when DNA repair is functional, FA might be causing cell death by damaging other cellular components rather than DNA

First, by drastically reducing systemic oxidative stress, it removes one of the primary physical triggers that cause mast cells to degranulate

Specifically, we obtained cis-eQTL data from the gene regions corresponding to the positive protein loci and used the effect of these eQTLs on gene expression ( SNP-eQTL ) along with their effect on migraine risk ( SNP-migraine ) to perform SMR analysis to estimate the potential causal effect of gene expression levels on migraine risk