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If you carry an emergency opioid overdose reversal medication, administer it immediately

NICE guideline NG28 for type 2 diabetes and technology appraisals for weight management formulations emphasise the importance of patient education and individualised care when initiating GLP-1 therapy

In some cases, a plateau indicates that the maximum benefit from the current dose has been reached and clinical reassessment including dose titration or addressing lifestyle factors is warranted

That could be 30 minutes a day for 5 days

Safety outcomes comprised acute kidney injury (AKI), severe hypoglycemia, treatment discontinuation due to adverse events, expanded major adverse cardiovascular events (MACE), and all-cause mortality