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More than 6 watery stools in 24 hours

If translated to humans, such multi-target strategies could better address the growing global burden of obesity and type 2 diabetes, though clinical validation, human safety testing, and mechanistic clarity remain essential

Trimethylaminuria is a rare disorder that causes a person to have an excess of the chemical trimethylamine in the body

Individuals with a personal or family history of thyroid tumours should be aware that, in common with other GLP-1 receptor agonists, retatrutide's GLP-1 activity may carry a theoretical thyroid risk

However, early research found that GLP-1 had a short half-life in the body, limiting its therapeutic potentialthe problem: it needed to last longer to reach the pancreas