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A total of 577 patients were randomly assigned (1:1:1) to receive once-weekly dulaglutide (1.5 mg), once-weekly dulaglutide (0.75 mg), or daily insulin glargine as basal therapy, all in combination with insulin lispro, for 52 weeks

The first published case of a significant tirzepatide injection site reaction described a progressive rash that enlarged over several days after administration, eventually covering the entire lower abdomen before resolving approximately one month after discontinuation

Understanding the frequency, severity, and management of these side effects is essential for providers in monitoring patients during treatment

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Bakuradze et al