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Things like GHRP3 can potently increase growth hormone, but are known to also potently increase prolactin and cortisol, leading to more than a doubling of circulating cortisol, which depending on how well regulated it is across the time of day can be problematic

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Seiwerth, S., Milavic, M., Vukojevic, J., et al

Jin X, Yao T, Zhou Z et al (2015) Advanced glycation end products enhance macrophages polarization into M1 phenotype through activating RAGE/NF-B Pathway