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Current UK guidance does not specifically recommend GLP-1 agonists for NAFLD treatment outside their licensed indications
Strongest human evidence The METAOD006 (OPTIONS) Phase 2b trial randomized 502 adults with obesity (BMI 30-45 kg/m^2) to oral AOD-9604 (0.25, 0.5, or 1 mg/day) or placebo for 24 weeks alongside a supervised diet and exercise program
Patients should undergo baseline assessments including hemoglobin A1c (for diabetes patients), renal function tests, and lipid panel
Fat loss, particularly visceral fat loss, takes time
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