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Permeability assays To establish the co-culture BBB model brain PCs were passaged at P11 (7 10 3 cells/insert) to the bottom (brain) side of culture inserts (polyester membrane
The field is so far proving to be unpredictable
[8] Novo Nordisk announced late at the 2025 European Association for the Study of Diabetes (EASD) annual meeting that in the REDEFINE 1 study, [9] cagrilintide provided clinically significant weight loss, with a mean reduction in body weight of 11.8% compared to 2.3% with placebo after 68 weeks, considering adherence of all participants to treatment
That said, the gap is shrinking, and future versions could make oral GLP-1s just as powerful as their injectable counterparts.
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