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The effect of the increased drug lipophilicity on BBB permeation can be attributed to greater nonspecific brain tissue binding in the brain parenchyma, leading to concentration gradients, which drive the transcellular passive diffusion (26)
Mitochondrial impairment and repair in the pathogenesis of systemic lupus erythematosus
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People with CVS may experience: Intense sweating Nausea, lasting from minutes to hours Appearing pale Vomiting Phase: This phase is characteristic of intense nausea and uncontrollable vomiting, often occurring multiple times per hour
