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BAT increases energy consumption by using acylcarnitine produced by the liver as a heat-producing fuel
In light of the narrow therapeutic window defined by the balance between glucose-lowering efficacy and (so-called) gastrointestinal side effects, it seems unlikely that future long-acting GLP-1 receptor agonists will provide substantially greater efficacy without inducing more side effects compared with the already available compounds
Suggested Research Combinations Tirzepatide a dual GIP/GLP-1 agonist, the standard comparator for isolating the glucagon receptor contribution
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