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In summary, semaglutide is an effective treatment that helps people with type 2 diabetes and other weight-related medical conditions successfully manage their symptoms and achieve better health outcomes

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[57] It does this by upregulating phosphorylated IRS-1 and activating pathways (like AMPK/SIRT1) that promote the transport of the GLUT4 glucose transporter to cell membranes in muscle and adipose tissue, thereby increasing overall cellular glucose uptake

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