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The GLP-1 component slows gastric emptying, reduces appetite through central nervous system pathways, and enhances glucose-dependent insulin secretion from pancreatic beta cells
Still, shifts in energy balance can have an impact on emotional states during the initial weeks of treatment
Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes
A comprehensive review published in Frontiers in Endocrinology (2024) further confirms that GLP-1 drugs reshape gastrointestinal physiology and metabolic regulation at multiple levels, affecting far more than just appetite
Note: Anti-Obesity GLP-1s Wegovy and Zepbound, Anti-Diabetes GLP-1s Ozempic and Mounjaro Source: IQVIA MAAS Patient Behavior Library Tool
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