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However, the definitive Exenatide-PD3 phase 3 trial , published in The Lancet in February 2025, found no disease-modifying benefit exenatide did not slow Parkinsons progression over 96 weeks compared to placebo in 194 patients ( [25] )
Continuing lifestyle changes and, if appropriate, transitioning to metformin or another agent can blunt rebound
Clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide) demonstrate that patients typically experience reduced caloric intake, with many reporting decreased interest in food and smaller portion sizes
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