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It serves an endocrine function, providing IGF1R activation to peripheral tissues distant from the production site

Electroporation buffer and unloaded RFP were removed by ultrafiltration via an Amicon centrifugal filter (Millipore, UFC510096, 100 kDa molecular weight cutoff) followed by three washes with DPBS buffer (10 mM, pH 7.4, 13,000 g) at 4 C

Honda, Y., Kessoku, T., Sumida, Y., Kobayashi, T., Kato, T., Ogawa, Y., Nakajima, A

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Holistic management involves routine screening for DPN and associated complications