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The mazdutide versus tirzepatide comparison is complicated by the fact that most mazdutide data comes from East Asian populations, which may respond differently to weight loss medications

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A pre-specified analysis of SELECT also demonstrated that semaglutide reduces kidney-related adverse events, including proteinuria and eGFR decline, the latter slope lowered by 0.39 mL min 1 1.73m 2 per year

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