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Safety Considerations and Who Should Prioritize Probiotic Support Probiotics are safe for most patients on tirzepatide, but immunocompromised individuals, those with short-bowel syndrome, or patients with central venous catheters should consult their provider first

Even more is that ~40-45% of patients lost at least 30% of their body weight and about 1 in 4 lost more than 35% of their body weight

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Several factors may explain urinary frequency changes, including improved blood sugar control, initial fluid shifts from weight loss, concurrent medications like SGLT2 inhibitors, or increased water intake

If nighttime urination (nocturia) disrupts sleep, reduce fluid intake 2-3 hours before bedtime while ensuring adequate daytime hydration