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Modulates inflammatory and tissue remodelling responses
Treatment with CD-PRX effectively mitigated MASH-related liver fibrosis by decreasing cholesterol accumulation and the profibrotic activation of macrophages surrounding dead hepatocytes with cholesterol crystals without affecting hepatic and serum levels of cholesterol [62]
The study was conducted in China by Hansoh Pharmaceutical Group , which holds development and commercialization rights for the therapy in Greater China, while Regeneron retains exclusive rights outside mainland China, Hong Kong and Macau under a strategic in-licensing agreement
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