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The body needs time to adjust, and making additional changes during this adjustment period complicates assessment

Proliferation (log 2 doublings, 5 days) of indicated UGDH-deficient cell lines expressing a sgRNA resistant UGDH cDNA or an empty vector under treatment with the indicated concentrations of ferrous ammonium citrate (FAC)

These changes were paralleled by elevated antioxidant capacity, as shown by increases in several antioxidant enzymes including SOD, catalase and glutathione peroxidase

The research brief recaps the discovery literature on selective androgen receptor modulation and emphasizes contexts where skeletal muscle and bone endpoints have been studied in preclinical systems, while also noting in vitro and neuronal model signals reported in the literature