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It is also researched in the context of circadian rhythm signaling and peptidergic neurotransmission in cellular and animal study models

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The synergy between these peptides occurs at multiple levels

Wang C, Jiang P, Sand C, Paul AV, Wimmer E (2012) Alanine scanning of poliovirus 2CATPase reveals new genetic evidence that capsid protein/2CATPase interactions are essential for morphogenesis

Here, after a brief review of the pathophysiology, we will focus on the advances in treatment of SCD that have occurred in the last 10 years and that have reached phase 2/3 of clinical trials (Figure 1)