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1 The SUSTAIN-2 trial demonstrated that adding semaglutide to metformin reduced HbA1c by 1.3-1.6% and led to weight loss of 4.3-6.1 kg over 56 weeks, compared to just 0.5% HbA1c reduction and 1.9 kg weight loss with sitagliptin added to metformin

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When administered as a once-daily subcutaneous injection, Saxenda acts on several mechanisms to promote weight loss: Appetite suppression : It acts on areas of the brain that regulate appetite, helping patients feel fuller for longer periods Delayed gastric emptying : The medication slows the rate at which food leaves the stomach, contributing to prolonged satiety Improved glucose regulation : It enhances insulin secretion when blood glucose levels are elevated According to the Summary of Product Characteristics (SmPC), Saxenda is licensed for adults with a body mass index (BMI) of 30 kg/m or greater, or 27 kg/m or greater in the presence of weight-related comorbidities such as hypertension, type 2 diabetes, dyslipidaemia, or obstructive sleep apnoea

This eating style helps consume more fiber keeps the person full for longer periods and aids in digestion thus helping to control weight

doi: 10.1016/j.jad.2016.09.056 13 KuchayMSKrishanSMishraSKChoudharyNSSinghMKWasirJSet al