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FDA reviewers identified one human study supporting the proposed indication of ulcerative colitis: a decades-old meeting abstract that was never published as a peer-reviewed trial and that used an oral route of administration rather than the injectable or subcutaneous routes that wellness clinics use

In the studied context, a review of six clinical trials found a safety profile comparable to placebo, without the IGF-1 effects of full growth hormone

No participants developed antibodies against the peptide, and no serious adverse events led to treatment withdrawal

MOTS-c's demonstrated ability to enhance both glucose utilization and fatty acid oxidation positions it as a potential modulator of this flexibility