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262,263 Although oligodendrocyte pathology is extensively explored in demyelinating disorders, accumulating evidence suggests its involvement in the pathogenesis of neurodegenerative diseases, including AD, 110 PD, 86 ALS, 89 and HD

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However, each member of the GPX family has a different mechanism of action and site of action in maintaining redox balance

The perspective outlined here emphasizes regenerative capacity relative to metabolic flux rather than absolute accumulation of reactive oxygen species