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Human clinical trial data remain sparse but are accumulating
This difference exists because oral semaglutide is absorbed through the stomach, while injectable semaglutide is absorbed through fatty tissue under the skin and enters the bloodstream directly
The takeaway is not that muscle loss on a GLP-1 is something to panic about
GLP-1 medications can impair B12 absorption through delayed gastric emptying and altered intrinsic factor activity
Larger, well-designed, randomized controlled trials are needed to resolve the existing uncertainties regarding weight loss and glycemic control outcomes in the long-term
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