Metabolic disorders such as obesity and diabetes are frequently associated with gut dysbiosis, characterized by reduced microbial diversity, loss of beneficial taxa, and increased inflammatory signatures, which contributes to insulin resistance and metabolic impairment ( Approved GLP-1 RAs include exendin-4based agents (exenatide, lixisenatide) and human GLP-1 analogues such as liraglutide, semaglutide, and dulaglutide
mRS 2 was considered as unfavorable outcome
Semaglutide : Selective GLP-1 receptor agonist that suppresses appetite, delays gastric emptying, and enhances glucose-dependent insulin secretion
Each approach has its own advantages and considerations
You should incorporate lean proteins, whole grains, vegetables and fruits, and healthy sources of fat into your diet