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Novo Nordisk conducted a randomized, double-blind, placebo-controlled phase 2b clinical trial called ELAD to evaluate the neuroprotective effects of liraglutide in patients with mild AD (Femminella et al., 2019)

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Further adequately powered prospective studies are required before combined SGLT2 inhibitor and GLP-1 receptor agonist therapy can be routinely recommended, specifically to improve heart failure outcomes

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