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Since there is no evidence in the literature for a direct or indirect effect of L-carnitine on COX4I1 and all other parameters related to the respiratory chain remained unaffected, this isolated effect cannot be plausibly explained
This suggests a wide range of potential applications for drugs targeting AHR
This altered hedonic response could reflect changes in gustatory processing or central integration of taste and reward signals
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PRECAUCIONES EN RELACIN CON EFECTOS DE CARCINOGNESIS, MUTAGNESIS, TERATOGNESIS Y SOBRE LA FERTILIDAD: L-carnitina no ha presentado efectos sobre la economa corporal de origen adverso, ya que siendo una sustancia que existe normalmente en el organismo, se han administrado dosis tan altas como 15 g/da sin producir carcinognesis, no hay evidencias de mutagnesis aun en Salmonella typhymurium, Saccharomyces cerevisae y Schizocharomyces pombe, no presentaron teratognesis ni efectos sobre la fertilidad, pues estudios a la dosis usual mxima en adultos sobre la base mg/kg, no han demostrado que la L-carnitina cause efectos adversos sobre el feto
