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GH acts on target tissues mainly via stimulation of the somatomedin insulin-like growth factor-1 (IGF-1, 7.6 kDa), and to a lesser extent, directly in an IGF-1 independent manner

In our experiment, rats were reared in the hypobaric oxygen chamber for 28 days to simulate a high-altitude environment

Y229 is positioned in an equivalent manner as in the GSTO1 C1-27 structure, but it does not interact with C4-10 , therefore is not shown in Supplementary Fig

Reported adverse effects include gastrointestinal discomfort and, in some people, a characteristic body odour