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In individuals with Type 2 Diabetes (T2D), there is an observed increase in Gram-negative Enterobacteriaceae and a concurrent decrease in acetic acid-producing bacteria, such as Bifidobacteria
Interestingly, a recent study revealed that commensal bacteria Bacteroides intestinalis and Lactobacillus johnsonii enriched by treatment of mushroom polysaccharides derived from Lyophyllum decastes were causally correlated with decreased plasma TG and LDL-C in HFD-induced obese mice through altering bile acid metabolism of gut microbiota (38), demonstrating a potential therapeutic approach of mushroom polysaccharides in the management of DM
Febbraio, M
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