It is used clinically and in research for tissue repair, with studies covering tendon and ligament injury, muscle strain, gut lining damage (including ulcers and inflammatory bowel conditions), and post-surgical recovery
Cardiovascular benefit occurs earlier with SGLT2 inhibitors and with greater weight on heart failure than with GLP-1 RAs, suggesting that the 2 classes reduce cardiovascular risk by different mechanisms, with GLP-1 RAs potentially having an antiatherothrombotic effect
Standard dosage: 200400 mg silymarin daily, divided into 23 doses Ideally taken before meals For liver stress: up to 420 mg silymarin daily may be appropriate only after medical consultation Alcohol should be avoided during intake Milk thistle preparations during pregnancy and breastfeeding should only be taken on the explicit recommendation of a doctor or midwife
Those using GLP-1 medications also had a reduced risk of seizures, suicidal ideation, self-harm, bulimia, and psychotic disorders such as schizophrenia
Pyatoykina AS, Zhilyaeva TV, Semennov IV, Mishanov GA, Blagonravova AS, Mazo GE