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If you pull it out too quickly, the medicine may not have fully come out of the pen, Connor says

Mild side effects and potential risks, which should be referred to a doctor if they persist or worsen, include: pain, redness, or itching at the site of the injection mild diarrhea swelling sensation in the body More serious side effects, which require immediate medical attention, include: muscle cramps irregular heartbeat unusual weakness or tiredness swelling of the ankles or feet Severe reactions are very rare but require emergency intervention

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Patients should never attempt to manipulate prefilled pens to achieve microdoses, as this risks dosing errors and contamination

After 12 weeks, the number of days with a migraine each month decreased from a mean of 19.8 days to just 10.7 days a reduction of nearly half