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administered hUC-MSCs to a CTX-induced POF model in Tibetan pigs, and their findings suggested that hUC-MSCs may inhibit apoptosis via regulation of the AKT/ERK1/2 signaling pathway
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Preclinical models and early-phase trials have shown motor improvement and graft survival, but issues such as immune rejection, tumorigenicity, and ethical concerns need resolution (Xiao and Tan, 2023
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