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Multiple rodent models of PCOS, capitalizing mainly on the impact of androgen excess at different developmental windows, with variable penetrance in terms of reproductive and metabolic impairment, have been used in translational studies, in order to capture the phenotypic heterogeneity of the syndrome 38
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There have been concerns about whether isotretinoin might affect growth, due to case reports of premature closure of the epiphyses (the growth areas at the ends of long bones) in the treatment of neuroblastoma, where much higher doses of this drug are given to younger children than what is typically prescribed for acne
GHK-Cu has a shorter window due to its copper component
This titration phase is designed to reduce the severity of gastrointestinal side effects
