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Levels of these metabolites were first normalized with the appropriate internal standard and then quantified to absolute concentration utilizing calibration curves obtained from the corresponding chemical standard (Five-concentration range from 0~55.4 mM)

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Additionally, real-world pharmacovigilance data highlight sensory adverse events (particularly dysgeusia) that appear more frequently in clinical practice than in controlled trials, suggesting under recognition of taste-related disturbances in research settings (159)