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Compound 102 exhibited GPX4 activating effects in a concentration-dependent manner ( Figure 3 and Supplementary Figure S3 ), with both increased ratio of 5-HETE and LTB 4 and increased concentrations of 12-HETE and 15-HETE
Theoretical Concerns From Mechanism While NNMT inhibition is a promising research target, the mechanism raises points that warrant caution in interpretation
Yan et al., 2022)
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