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The relationship between the AGE-RAGE system and infertility was also documented: AGEs have a negative effects on the reproductive outcome in women undergoing ART (assisted reproduction technology), AGE high levels in NON PCOS women appear to be related to the decrease in ovarian reserve and abnormal folliculogenesis
doi: 10.3389/fimmu.2022.920147, 29
Taken together, the results corroborated that GSH inhibited PSC activation via down-regulation of the TGF-/SMAD pathway
[2] YOUNG-HOON JUNG
2.2.2 Anti-inflammatory DPP-4 is expressed at macrophages, binds to adenosine deaminase, and exhibits a nonenzymatic function that contributes to T cell proliferation and activation [2]
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