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Extra fat cells act like mini chemical factories, releasing hormones and inflammatory messengers called cytokines, such as interleukin-6 (IL-6), Tumor necrosis factor alpha (TNF-alpha), interleukin-17 (IL-17), and others
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SNPs in genes such as GSS, ABCC2, and XRCC1 affect metabolic and DNA damage repair capacities, modulating patient response to treatment and impacting prognosis
Cazenave LA et al
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