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But a recent mouse study showed that semaglutide doesnt really target these preproglucagon neurons and instead acts more on the peripheral systems.[ref] GLP-1 receptors are also found on pancreatic beta cells, triggering insulin release

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Rare cases of drug-induced liver injury have been reported, but routine hepatotoxicity is not characteristic of semaglutide

as the disease becomes prolonged, these abnormalities appear to subside and T-cell exhaustion becomes evident (225, 254)