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All SAEs will be followed up until satisfactory resolution or until the treating physicians and the principal investigator deem the event to be chronic or the participant to be stable

2007 Aug;7(4):355-9

Depending on your starting skin tone, it can take anywhere from three months to two years of consistent use to see results

What this data doesn't tell us: whether NNMT suppression sustained beyond 12 weeks alters NAD+ metabolism in ways that affect mitochondrial function, whether methylation pathway compensation occurs over longer timescales, or whether adipose tissue remodeling continues linearly or plateaus