Acknowledgements ChatGPT was used in some places in the manuscript to suggest edits to the text and proper word usage and grammar
Totally, 4,620 movies were obtained with a defocus range of -1.2 to -2.2 m
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Summary: Saxenda does not directly cause sore throat, but upper respiratory infections and nasopharyngitis are recognised adverse reactions that may present with throat symptoms
Studies also show that a ketogenic diet or BHB treatment can activate the major detoxification and oxidative stress nuclear factor erythroid 2-related factor 2 (Nrf2) pathway.53 In a spontaneous mouse model of T2D (db/db mice) treated with dapagliflozin, there was a noticeable reduction in the expression of genes related to oxidative stress compared with those treated with a standard vehicle or glimepiride.54 This reduction is associated with increased levels of BHB and NRF2 protein expression.54 Similarly, BHB treatment in human proximal tubular cells (HK-2) led to increased NRF2 expression and induced NRF2 nuclear translocation.55 Furthermore, a ketogenic diet has been reported to increase the expression of other antioxidants such as NAD(P)H dehydrogenase quinone I (NQO1) and superoxide dismutase (SOD1/2),56 and ameliorated paraquat (PQ)-induced elevated lipid peroxidation, toxicity, reduced antioxidant activity and decreased Nrf2 expression,57 highlighting its potential therapeutic role in combating oxidative stress and tissue hypoxia
