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Figure 5 Downstream cellular mediators of Dihexa protection Activation of the receptor tyrosine kinase c-Met leads to the recruitment of many signaling mediators and ultimately the activation of downstream signals, most notably Akt-TOR and Ras-ERK (Organ and Tsao, 2011)

There is a highly developed cytoskeleton system in eukaryotic cells with microfilaments and microtubules as important components of the cytoskeleton

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Since the radiation-induced pneumonitis/fibrosis is marked by an inflammatory response, the above observation suggested the probable role of seleno-GPxs in modulating the radiation-induced inflammatory responses (Fig

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