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In addition, both TTP and gAgAP downregulated transcription levels of angiotensin II receptor type 1 ( agtr1 ) and miR-132/-212, with TTP producing a comparable reduction in agtr1 to captopril and a significant decrease in miR-132/-212 expression
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It tracks closely with the metabolic deterioration that characterizes the third and fourth decades of life: rising fasting insulin, expanding visceral adipose tissue, declining mitochondrial density in skeletal muscle, and blunted exercise adaptability
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