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On the other hand, the risks of HHF (HR 0.93, 95% CI 0.831.04 with GLP-1RAs and HR 0.69, 95% CI 0.610.79 with SGLT2is) and composite kidney outcomes excluding macroalbuminuria (HR 0.92, 95% CI 0.801.06 with GLP-1RAs and HR 0.55, 95% CI 0.480.64 with SGLT2is) significantly reduced with SGLT2is only
Obesity is a chronic, systemic disease driven by excess adiposity that can cause severe organ dysfunction and lifethreatening complications (for example, stroke, cardiovascular disease, type 2 diabetes, depression, and certain cancers) [1,2]
It takes about 4-5 weeks to reach steady-state concentrations in your body, which means the full effect builds gradually, making patience and consistency essential
It is not known if semaglutide will cause thyroid tumors or a type of thyroid cancer called medullary thyroid carcinoma (MTC) in humans
While the absolute risk of thyroid malignancy remains very low, early detection of any thyroid pathology improves outcomes
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