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Nicotinic acid was the first hypolipidemic agent shown to decrease the incidence of secondary myocardial infarction (MI) and reduce total mortality in MI patients
In the IFIGENIA study, adding NAC 600 mg/day to prednisone and azathioprine slowed lung function decline and improved Diffusing Capacity of the Lung for Carbon Monoxide (DLCO), especially in early IPF (136, 137)
Although the majority of readouts are at bulk level, mitochondrial changes in mass and morphology at single-cell resolution suggest an adaptive response rather than a selection for pre-existing tolerant cells in clonal lines
Redox Signal 36 , 12681288 (2022)
In addition to MnO2, other transition metal oxides like Co3O4 and CeO2, which can react with GSH, can also be used to design GSH-responsive DDSs [69]
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